A Non-invasive Method to Assess Hepatic Acetyl-CoA In Vivo
نویسندگان
چکیده
منابع مشابه
Hepatic Acetyl CoA Links Adipose Tissue Inflammation to Hepatic Insulin Resistance and Type 2 Diabetes
Impaired insulin-mediated suppression of hepatic glucose production (HGP) plays a major role in the pathogenesis of type 2 diabetes (T2D), yet the molecular mechanism by which this occurs remains unknown. Using a novel in vivo metabolomics approach, we show that the major mechanism by which insulin suppresses HGP is through reductions in hepatic acetyl CoA by suppression of lipolysis in white a...
متن کاملCurrent Status of Non-invasive Alternatives to Liver Biopsy to Assess Hepatic Fibrosis
• The extent of hepatic fibrosis in patients with chronic liver disease is associated with the risk of hepatic morbidity and mortality via the development of portal hypertension and liver cancer. • Ideal features of a non-invasive test of hepatic fibrosis include simplicity, reproducibility, accuracy, association with disease severity, improvement with therapy, association with clinical outcome...
متن کاملA Non-Invasive Method to Assess Cerebral Perfusion Pressure in Geriatric Patients with Suspected Cerebrovascular Disease
BACKGROUND Cerebral perfusion pressure (CPP) can adversely impact cerebrovascular hemodynamics but cannot be practically measured in most clinical settings. Here, we aimed to establish a representative mathematical model for CPP in geriatric patients with suspected cerebrovascular disease. METHODS A total of 100 patients (54 males and 46 females between 60-80 years of age) with suspected cere...
متن کاملQuantitative micro-computed tomography: a non-invasive method to assess equivalent bone mineral density.
One of the many applications of micro computed tomography (microCT) is to accurately visualize and quantify cancellous bone microstructure. However, microCT based assessment of bone mineral density has yet to be thoroughly investigated. Specifically, the effects of varying imaging parameters, such as tube voltage (kVp), current (microA), integration time (ms), object to X-ray source distance (m...
متن کاملConstruction of new forms of pyruvate carboxylase to assess the allosteric regulation by acetyl-CoA.
The single polypeptide chain of Bacillus thermodenitrificans pyruvate carboxylase (PC) is composed of the biotin carboxylase (BC), carboxyl transferase (CT) and biotin carboxyl carrier protein (BCCP) domains from the amino terminus. This polypeptide chain was divided into two between the CT and BCCP domains. The resulting proteins, PC-(BC + CT) and PC-(BCCP), were expressed in Escherichia coli ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell Metabolism
سال: 2017
ISSN: 1550-4131
DOI: 10.1016/j.cmet.2016.12.017